hedgehog inhibitor Search Results


hedgehog pathway inhibitors  (Infinity Pharmaceuticals)
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Infinity Pharmaceuticals hedgehog pathway inhibitors
Hedgehog Pathway Inhibitors, supplied by Infinity Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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polymeric nanoparticle encapsulated small-molecule inhibitor of hedgehog signaling (nanohhi)  (Nanoworld Services GmbH)
90
Nanoworld Services GmbH polymeric nanoparticle encapsulated small-molecule inhibitor of hedgehog signaling (nanohhi)
Polymeric Nanoparticle Encapsulated Small Molecule Inhibitor Of Hedgehog Signaling (Nanohhi), supplied by Nanoworld Services GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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novel inhibitor of the hedgehog signaling pathway  (Chemie GmbH)
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Chemie GmbH novel inhibitor of the hedgehog signaling pathway
Novel Inhibitor Of The Hedgehog Signaling Pathway, supplied by Chemie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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smo/gli multitarget hedgehog pathway inhibitor  (MultiTarget Pharmaceuticals)
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MultiTarget Pharmaceuticals smo/gli multitarget hedgehog pathway inhibitor
Smo/Gli Multitarget Hedgehog Pathway Inhibitor, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hedgehog inhibitor pf-04449913  (Pfizer Inc)
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Pfizer Inc hedgehog inhibitor pf-04449913
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hedgehog inhibitor  (Genentech inc)
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Genentech inc hedgehog inhibitor
Hedgehog Inhibitor, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hedgehog signaling inhibitor vismodegib  (LC Laboratories)
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hedgehog pathway inhibitors  (Regeneron inc)
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Regeneron inc hedgehog pathway inhibitors
Hedgehog Pathway Inhibitors, supplied by Regeneron inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hedgehog inhibitors cyclopamine  (LC Laboratories)
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LC Laboratories hedgehog inhibitors cyclopamine
Changes in (a) PDPK1, (b) p-Akt, and (c) Hedgehog expression in H146 cells after the transfection of PDPK1 siRNA, Akt siRNA, constitutively active PDPK1, and constitutively active Akt. (d) p-Akt and Akt expression and the p-Akt/Akt ratio following PDPK1 siRNA transfection. (e) Hedgehog protein expression following transfection with constitutively active PDPK1 and constitutively active Akt. (f–g) PDPK1 and p-Akt expression after treatment with the Hedgehog <t>inhibitors</t> <t>cyclopamine</t> and GDC-0449. & P < 0.05 versus scrambled siRNA transfection. PDPK1, phosphoinositide-dependent kinase-1.
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hedgehog inhibitors cyclopamine cayman chemicals  (Cayman Chemical)
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Cayman Chemical hedgehog inhibitors cyclopamine cayman chemicals
LRP1 and cholesterol loading in hepatocytes act synergistically to activate hepatic stellate cells via the sonic hedgehog pathway. Primary hepatocytes isolated from hLrp1+/+ (filled bars) and hLrp1−/− (open bars) mice were incubated without (control) or with 20 μm cholesterol (+ chol) for 16 h. Conditioned media from these cell cultures were added to the T6 hepatic stellate cells, and incubation was continued for an additional 24 h in the presence or absence of a 10 μm concentration of the hedgehog signaling inhibitor <t>cyclopamine</t> or GANT-58. Total cellular RNA was isolated for RT-qPCR analysis of smooth muscle α-actin (A), desmin (B), and TGF-β (C). The data were analyzed using cyclophilin mRNA levels as control. Expression levels observed when T6 cells were incubated with hLrp1+/+ hepatocyte conditioned medium in the absence of cholesterol were set as 1.0. The data represent mean ± S.E. from duplicate experiments, each performed with three biological replicate samples. *, significant differences at p < 0.05.
Hedgehog Inhibitors Cyclopamine Cayman Chemicals, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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innovativer hedgehog-signalweg-inhibitor  (Verlag GmbH)
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Verlag GmbH innovativer hedgehog-signalweg-inhibitor
LRP1 and cholesterol loading in hepatocytes act synergistically to activate hepatic stellate cells via the sonic hedgehog pathway. Primary hepatocytes isolated from hLrp1+/+ (filled bars) and hLrp1−/− (open bars) mice were incubated without (control) or with 20 μm cholesterol (+ chol) for 16 h. Conditioned media from these cell cultures were added to the T6 hepatic stellate cells, and incubation was continued for an additional 24 h in the presence or absence of a 10 μm concentration of the hedgehog signaling inhibitor <t>cyclopamine</t> or GANT-58. Total cellular RNA was isolated for RT-qPCR analysis of smooth muscle α-actin (A), desmin (B), and TGF-β (C). The data were analyzed using cyclophilin mRNA levels as control. Expression levels observed when T6 cells were incubated with hLrp1+/+ hepatocyte conditioned medium in the absence of cholesterol were set as 1.0. The data represent mean ± S.E. from duplicate experiments, each performed with three biological replicate samples. *, significant differences at p < 0.05.
Innovativer Hedgehog Signalweg Inhibitor, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hedgehog pathway inhibitors  (Novartis)
90
Novartis hedgehog pathway inhibitors
LRP1 and cholesterol loading in hepatocytes act synergistically to activate hepatic stellate cells via the sonic hedgehog pathway. Primary hepatocytes isolated from hLrp1+/+ (filled bars) and hLrp1−/− (open bars) mice were incubated without (control) or with 20 μm cholesterol (+ chol) for 16 h. Conditioned media from these cell cultures were added to the T6 hepatic stellate cells, and incubation was continued for an additional 24 h in the presence or absence of a 10 μm concentration of the hedgehog signaling inhibitor <t>cyclopamine</t> or GANT-58. Total cellular RNA was isolated for RT-qPCR analysis of smooth muscle α-actin (A), desmin (B), and TGF-β (C). The data were analyzed using cyclophilin mRNA levels as control. Expression levels observed when T6 cells were incubated with hLrp1+/+ hepatocyte conditioned medium in the absence of cholesterol were set as 1.0. The data represent mean ± S.E. from duplicate experiments, each performed with three biological replicate samples. *, significant differences at p < 0.05.
Hedgehog Pathway Inhibitors, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Changes in (a) PDPK1, (b) p-Akt, and (c) Hedgehog expression in H146 cells after the transfection of PDPK1 siRNA, Akt siRNA, constitutively active PDPK1, and constitutively active Akt. (d) p-Akt and Akt expression and the p-Akt/Akt ratio following PDPK1 siRNA transfection. (e) Hedgehog protein expression following transfection with constitutively active PDPK1 and constitutively active Akt. (f–g) PDPK1 and p-Akt expression after treatment with the Hedgehog inhibitors cyclopamine and GDC-0449. & P < 0.05 versus scrambled siRNA transfection. PDPK1, phosphoinositide-dependent kinase-1.

Journal: The Journal of International Medical Research

Article Title: Possible involvement of the Hedgehog and PDPK1–Akt pathways in the growth and migration of small-cell lung cancer

doi: 10.1177/03000605211016562

Figure Lengend Snippet: Changes in (a) PDPK1, (b) p-Akt, and (c) Hedgehog expression in H146 cells after the transfection of PDPK1 siRNA, Akt siRNA, constitutively active PDPK1, and constitutively active Akt. (d) p-Akt and Akt expression and the p-Akt/Akt ratio following PDPK1 siRNA transfection. (e) Hedgehog protein expression following transfection with constitutively active PDPK1 and constitutively active Akt. (f–g) PDPK1 and p-Akt expression after treatment with the Hedgehog inhibitors cyclopamine and GDC-0449. & P < 0.05 versus scrambled siRNA transfection. PDPK1, phosphoinositide-dependent kinase-1.

Article Snippet: To confirm the effects of Hedgehog in normal lung epithelial and SCLC cell functioning (migration and proliferation), we treated BEAS-2B and H146 cells with the Hedgehog inhibitors cyclopamine (LC Laboratories, Woburn, MA, USA) and GDC-0449 (LC Laboratories) at a concentration of 1 μM for 72 hours, then measured cell viability and migration.

Techniques: Expressing, Transfection

Effects of Hedgehog inhibitors on the proliferation of (a) BEAS-2B and (b) H146 cells. BEAS-2B and H146 cells were treated with cyclopamine and GDC-0449, and proliferation and migration were evaluated using Cell Counting Kit-8. # P < 0.05 versus the scrambled siRNA group. PDPK1, phosphoinositide-dependent kinase-1.

Journal: The Journal of International Medical Research

Article Title: Possible involvement of the Hedgehog and PDPK1–Akt pathways in the growth and migration of small-cell lung cancer

doi: 10.1177/03000605211016562

Figure Lengend Snippet: Effects of Hedgehog inhibitors on the proliferation of (a) BEAS-2B and (b) H146 cells. BEAS-2B and H146 cells were treated with cyclopamine and GDC-0449, and proliferation and migration were evaluated using Cell Counting Kit-8. # P < 0.05 versus the scrambled siRNA group. PDPK1, phosphoinositide-dependent kinase-1.

Article Snippet: To confirm the effects of Hedgehog in normal lung epithelial and SCLC cell functioning (migration and proliferation), we treated BEAS-2B and H146 cells with the Hedgehog inhibitors cyclopamine (LC Laboratories, Woburn, MA, USA) and GDC-0449 (LC Laboratories) at a concentration of 1 μM for 72 hours, then measured cell viability and migration.

Techniques: Migration, Cell Counting

Effects of the Hedgehog inhibitors cyclopamine and GDC-0449 on the invasiveness and migration of H146 cells. Following treatment, (a and c) wound closure and (b and d) migration were evaluated. # P < 0.05 versus the scrambled siRNA group. PDPK1, phosphoinositide-dependent kinase-1.

Journal: The Journal of International Medical Research

Article Title: Possible involvement of the Hedgehog and PDPK1–Akt pathways in the growth and migration of small-cell lung cancer

doi: 10.1177/03000605211016562

Figure Lengend Snippet: Effects of the Hedgehog inhibitors cyclopamine and GDC-0449 on the invasiveness and migration of H146 cells. Following treatment, (a and c) wound closure and (b and d) migration were evaluated. # P < 0.05 versus the scrambled siRNA group. PDPK1, phosphoinositide-dependent kinase-1.

Article Snippet: To confirm the effects of Hedgehog in normal lung epithelial and SCLC cell functioning (migration and proliferation), we treated BEAS-2B and H146 cells with the Hedgehog inhibitors cyclopamine (LC Laboratories, Woburn, MA, USA) and GDC-0449 (LC Laboratories) at a concentration of 1 μM for 72 hours, then measured cell viability and migration.

Techniques: Migration

LRP1 and cholesterol loading in hepatocytes act synergistically to activate hepatic stellate cells via the sonic hedgehog pathway. Primary hepatocytes isolated from hLrp1+/+ (filled bars) and hLrp1−/− (open bars) mice were incubated without (control) or with 20 μm cholesterol (+ chol) for 16 h. Conditioned media from these cell cultures were added to the T6 hepatic stellate cells, and incubation was continued for an additional 24 h in the presence or absence of a 10 μm concentration of the hedgehog signaling inhibitor cyclopamine or GANT-58. Total cellular RNA was isolated for RT-qPCR analysis of smooth muscle α-actin (A), desmin (B), and TGF-β (C). The data were analyzed using cyclophilin mRNA levels as control. Expression levels observed when T6 cells were incubated with hLrp1+/+ hepatocyte conditioned medium in the absence of cholesterol were set as 1.0. The data represent mean ± S.E. from duplicate experiments, each performed with three biological replicate samples. *, significant differences at p < 0.05.

Journal: The Journal of Biological Chemistry

Article Title: Low-density lipoprotein receptor–related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression

doi: 10.1074/jbc.RA118.001952

Figure Lengend Snippet: LRP1 and cholesterol loading in hepatocytes act synergistically to activate hepatic stellate cells via the sonic hedgehog pathway. Primary hepatocytes isolated from hLrp1+/+ (filled bars) and hLrp1−/− (open bars) mice were incubated without (control) or with 20 μm cholesterol (+ chol) for 16 h. Conditioned media from these cell cultures were added to the T6 hepatic stellate cells, and incubation was continued for an additional 24 h in the presence or absence of a 10 μm concentration of the hedgehog signaling inhibitor cyclopamine or GANT-58. Total cellular RNA was isolated for RT-qPCR analysis of smooth muscle α-actin (A), desmin (B), and TGF-β (C). The data were analyzed using cyclophilin mRNA levels as control. Expression levels observed when T6 cells were incubated with hLrp1+/+ hepatocyte conditioned medium in the absence of cholesterol were set as 1.0. The data represent mean ± S.E. from duplicate experiments, each performed with three biological replicate samples. *, significant differences at p < 0.05.

Article Snippet: The hedgehog inhibitors cyclopamine (Cayman Chemicals) and GANT-58 (Cayman Chemicals) were included in selected cultures at 10 μ m concentrations.

Techniques: Isolation, Incubation, Control, Concentration Assay, Quantitative RT-PCR, Expressing